{"id":33,"date":"2018-09-06T15:58:47","date_gmt":"2018-09-06T06:58:47","guid":{"rendered":"https:\/\/josai-pharm.jp\/wp\/?page_id=33"},"modified":"2025-05-02T09:17:07","modified_gmt":"2025-05-02T00:17:07","slug":"%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/josai-pharm.jp\/?page_id=33","title":{"rendered":"\u696d\u7e3e Research Achievements\u00a0"},"content":{"rendered":"\n

\u8ad6\u6587Articles <\/h1>\n\n\n\n

2025\u5e74<\/h3>\n\n\n\n
  1. H. Shirai, M. Taneda, H. Koito, R. Suzuki, The constituents of Mallotus Bark showing antibacterial activity against Vibrio vulnificus<\/em>, Japan. J. Pharmacog<\/em>., 79<\/strong>, 63\u201364 (2025).<\/li>
  2. A. Sano, R. Suzuki, Isolation of compounds including two new compounds from asiasarum root and their anti-glycation activity. Chem. Pharm. Bull<\/em>., accepted.<\/li><\/ol>\n\n\n\n

    2024\u5e74<\/h3>\n\n\n\n
    1. \u9234\u6728\u9f8d\u4e00\u90ce\u3001\u5c71\u4e0b\u606f\u5439\u3001\u4f50\u91ce\u611b\u5b50\uff0c5\u03b1\uff0d\u30ea\u30c0\u30af\u30bf\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u7cbe\u6cb9\u306e\u63a2\u7d22\uff0c\u30a2\u30ed\u30de\u30c6\u30e9\u30d4\u30fc\u5b66\u96d1\u8a8c\uff0c25<\/strong>, 19\u201324 (2024).<\/li>
    2. T. Shii, T. Iguchi, M. Kuroda, T. Shimazaki, R. Suzuki, Y. Mimaki, Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products, Tradit. Kampo Med<\/em>.,11<\/strong>, 13\u201321 (2024).<\/li>
    3. Y. Kiba, T. Tanikawa, T. Hayashi, T. Yokogawa, A. Sano, R. Suzuki, M. Kitamura, Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro, J. Nat. Med<\/em>., 78<\/strong>, 784\u2013791, (2024).<\/li>
    4. A. Sano, Y. Inoue, Y. Higuchi, K. Akao, R. Suzuki, Quality control of corn silk extract using IR spectroscopy along with statistical methods., Anal. Sci<\/em>., 41, 311-316 (2024).<\/li><\/ol>\n\n\n\n

      2023\u5e74<\/h3>\n\n\n\n
      1. R. Suzuki , Y. Shirataki, A. Tomomura, K. Bandow, H. Sakagami, M. Tomomura, Isolation of pro-osteogenic compounds from Euptelea polyandra that reciprocally regulate osteoblast and osteoclast differentiation. Int J Mol Sci<\/em>, 24<\/strong>, 17479 (2023).<\/li>
      2. A. Sano, T. Shibata, A. Takahasi, T. Yokogawa, M. Kitamura, R. Suzuki, Discrimination of Sayamakaori and Yabukita which are original plant source of Japanese Green Tea and identification of specific compounds for the former by NMR metabolomics techniques combined with isolation by chromatography methods. Nat. Prod. Commun<\/em>., 18<\/strong>, 1 – 7 (2023).<\/li>
      3. R. Suzuki, R. Yumoto, H. Shirai, T. Tanaka, Anti-Helicobacter pylori activity of Swertianolin, isolated from swertia herb. J. Nat. Med<\/em>. , 77<\/strong>, 1005 – 1008 (2023).<\/li>
      4. T. Shii, T. Iguchi, M. Kuroda, T. Shimazaki, R. Suzuki, Y. Mimaki, Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products. Traditional & Kampo Medicine<\/em>, 1 – 9 (2023).<\/li>
      5. H. Saito, S. Miyoshi, T. Murakami, R. Suzuki, Differentiating Between Three Licorice Species Using SFC-TOF\/MS Analysis With Principal Component Analysis. Nat. Prod. Commun<\/em>., 18<\/strong>, 1 – 10 (2023).<\/li>
      6. Y. Kiba, T. Tanikawa, T. Hayashi, H. Kamauchi, T. Seki, R. Suzuki, M. Kitamura, Inhibition of furin-like enzymatic activities and SARS-CoV-2 infection by osthole and phenolic compounds with aryl side chains. Biomedicine & Pharmacotherapy<\/em>, 169<\/strong>, 115940, (2023).<\/li>
      7. Takami Y., Chiaki Y., Mari H., Yuka S., Takashi T., Ryuichiro S., Yutaka I., Masashi K., Effect of Maillard reaction on the quality of clarified butter, ghee, J. Nat. Med<\/em>., 77<\/strong>, 230 – 237, (2023).<\/li><\/ol>\n\n\n\n

        2022\u5e74<\/h3>\n\n\n\n
        1. R. Suzuki<\/u>, Y. Kasuya, A. Sano, J. Tomita, T. Maruyama, M. Kitamura, Comparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods. J. Nat. Med<\/em>., 76<\/strong>, 87-93 (2022).<\/li>
        2. A. Sano, Y. Inoue, R. Suzuki<\/u>, Lignin, an active component in the corn silk water extract, inhibits glycation, Scientific Reports<\/em>, 12<\/strong>, 17764 (2022).<\/li>
        3. Y. Ueno, R. Suzuki<\/u>, M. Kitamura, 1<\/sup>H-NMR-based metabolomics for the classification of the roots of Paeonia lactiflora,<\/em> a constituent of Kampo medicines. Chem. Pharm. Bull<\/em>., 70<\/strong>, 859-862 (2022).<\/li>
        4. T. Tanikawa, Y. Kiba, J. Yu, K. Hsu, S. Chen, A. Ishii, T. Yokogawa, R. Suzuki<\/u>, Y. Inoue, M. Kitamura, Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2, Molecules<\/em>, 27<\/strong>, 5405 (2022).<\/li>
        5. M. Kitamura, N. Muramatsu, T. Yokogawa, Y. Kiba, R. Suzuki<\/u>, Fruit body formation and intra-species DNA polymorphism in Japanese Wolfiporia cocos<\/em> strains. J. Nat. Med<\/em>., 76<\/strong>, 675-679 (2022).<\/li>
        6. K. Yoshimura, A. Sano, R. Suzuki<\/u>, S. Mitomo, Y. Negishi, T. Mutai, Jr, Florencio Arce, \u202aGerard Lee See, T. Tanikawa, Y. Inoue. Determination of Sugars and Amino Acids in Japanese Wine using Core-Shell Liquid Chromatography tandem Electrochemical Detection. Thai J. Pharm. Sci<\/em>., in press.<\/li>
        7. T. Tanikawa, T. Hayashi, R. Suzuki<\/u>, M. Kitamura, Y. Inoue, Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2infection. J. Tradit. Complement Med<\/em>., 12, 69-72 (2022).<\/li><\/ol>\n\n\n\n

          2021\u5e74<\/h3>\n\n\n\n
          1. R. Suzuki<\/u>, Y. Uesawa, Y. Okada, T. Horikawa, Y. Okabe, M. Aburada, K. Takahashi, K. Kinoshita. Use of 13<\/sup>C-NMR chemical shifts; Application of principal component analysis for categorizing structurally similar methoxyflavones and correlation analysis between chemical shifts and cytotoxicity. Chem. Pharm. Bull<\/em>., 69<\/strong>,199-202 (2021).<\/li>
          2. Y.Kiba, R. Oyama, S. Misawa, T. Tanikawa, M. Kitamura, R. Suzuki<\/u>. Screening for inhibitory effects of crude drugs on furin-like enzymatic activities. J. Nat. Med<\/em>., 75<\/strong>, 1080\u20131085 (2021).<\/li>
          3. T. Tanikawa, T. Hayashi, R. Suzuki<\/u>, M. Kitamura, Y. Inoue, Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2infection. J. Tradit. Complement Med<\/em>., 2021 Sep 16. doi: 10.1016\/j.jtcme.2021.09.005.<\/li>
          4. K. Yoshimura, A. Sano, R. Suzuki<\/u>, S. Mitomo, Y. Negishi, T. Mutai, Jr, Florencio Arce, \u202aGerard Lee See, T. Tanikawa, Y. Inoue. Determination of Sugars and Amino Acids in Japanese Wine using Core-Shell Liquid Chromatography tandem Electrochemical Detection. Thai J. Pharm<\/em>. Sci., in press.<\/li><\/ol>\n\n\n\n

            2020\u5e74<\/h3>\n\n\n\n
            1. R. Suzuki<\/u>, H. Ohno, T. Murakami, and Y. Shirataki, Improving quality control of yucca extracts used as food additives by screening antimicrobial activity using NMR metabolomics. J. Nat. Med<\/em>., 74<\/strong>, 306-310 (2020).<\/li>
            2. K. Sugibayashi, Y. Yoshida, R. Suzuki<\/u>, K. Yoshizawa, K. Mori, S. Itakura, K. Takayama, H. Todo, Physical Properties of an Ionic Liquid Composed of Two Water-Soluble Vitamins and Enhanced Skin Permeation of Both Vitamins. Pharmaceutics<\/em>, 12<\/strong>, 427 (2020).<\/li>
            3. M. Kitamura, Y. Kiba, R. Suzuki<\/u>, N. Tomida, A. Uwaya, F. Isami, S. Deng, Cannabidiol Content and In Vitro Biological Activities of Commercial Cannabidiol Oils and Hemp Seed Oils. Medicines<\/em>, 7<\/strong>, 57 (2020).<\/li>
            4. S. Misawa, D. Natsuhara, Y. Kiba, T. Yamamuro, R. Suzuki<\/u>, T. Shibata, M. Kitamura, Rapid identification of Colchicum autumnale based on loop-mediated isothermal amplification (LAMP) assay. Forensic Toxicol.<\/em>, Published online. 04, November (2020).<\/li><\/ol>\n\n\n\n
              \n\n\n\n

              2019\u5e74<\/h3>\n\n\n\n
              1. Utsumi, R. Suzuki<\/u>, H. Kamauchi, S. Misawa, M. Kitamura, Y. Sugita, and Y. Shirataki, A New \u03b3-Butenolide Glycoside from the Root of Styphnolobium japonicum<\/em>. Heterocycles,<\/em> 98<\/strong>, 1251-1257 (2019).<\/li>
              2. M. Kitamura, N. Muramatsu, R. Suzuki<\/u>, Y. Shirataki, Authentication of shan-dou-gen based on DNA analysis, Nat. Prod. Commum<\/em>., 14, 1-5 (2019).<\/li>
              3. Masashi Kitamura, Akira Kazato, Tadashi Yamamuro, Hirokazu Ando, Yohei Sasaki, Ryuichiro Suzuki<\/u>, Yoshiaki Shirataki, Rapid identification of Aconitum plants based on loop-\u200bmediated isothermal amplification assay, BMC Research Notes, 12, 1-5 (2019).<\/li>
              4. R. Suzuki<\/u>, U. Takahiro, R. Takao and Y. Shiratak, Nor-kurarinone characteristic of Chinese Sophora flavescens<\/em>, Nat. Prod. Commum<\/em>., 14, 107-109 (2019).<\/li>
              5. R. Suzuki<\/u>, S. Fukami, M. Tomomura, A. Tomomura, Y. Shirataki, Screening for natural medicines effective for the treatment of osteoporosis, J. Nat. Med<\/em>., 73, 331-337 (2019).<\/li><\/ol>\n\n\n\n
                \n\n\n\n

                2018\u5e74<\/h3>\n\n\n\n
                1. R. Suzuki<\/u><\/strong>, T. Kawasaki, Y. Honda, S. Fujita, Y. Shirataki, Effects of Oolong Tea on Postprandial Triglyceride Levels, Jpn. Pharmacol. Ther., 46<\/strong>, 1339-1346 (2018).<\/li>
                2. R. Takao, R. Suzuki<\/u><\/strong>, M. Ueki, Y. Sugiura, Y. Shirataki, Metabolites of Endophytic Actinomycetes Isolated from Sophora flavescens, Japan. J. Pharmacog., 72<\/strong>, 90-91 (2018).<\/li>
                3. R. Suzuki<\/u><\/strong>, F. Nakano, H. Ohno, T. Murakami, Y. Okada and Y. Shirataki, Distinguishing Glycyrrhiza species using NMR-based metabolomics, Nat. Prod. Commun., 13<\/strong>, 71-73 (2018).<\/li><\/ol>\n\n\n\n
                  \n\n\n\n

                  2017\u5e74<\/h3>\n\n\n\n
                  1. H. Sakagami, R. Suzuki<\/u><\/strong>, Y. Shirataki, S. Iwama, M. Nakagawa, H. Suzuki, K.Tanaka, N. Tamura and H. Takeshima, Re-evaluation of Culture Condition of PC12 and SH-SY5YCells Based on Growth Rate and Amino Acid Consumption, in vivo, 31<\/strong>, 1089-1095 (2017).<\/li>
                  2. R. Suzuki<\/u><\/strong>, S. Kan, Y. Sugita and Y. Shirataki, p-Coumaroyl malate derivatives of the Pandanus amaryllifolius leaf and their isomerization, Chem. Pharm. Bull., 65, 1191-1194 (2017).<\/li>
                  3. R. Suzuki<\/u><\/strong>, H. Sakagami, S. Amano, K. Fukuchi, K. Sunaga, T. Kanamoto, S. Terakubo, H. Nakashima, Y. Shirataki, M. Tomomura, Y. Masuda, S. Yokose, A. Tomomura, H. Watanabe, M. Okawara and Y. Matahira, Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices, in vivo, 31<\/strong>: 591-598 (2017).<\/li>
                  4. H. Kai, K. Kinoshita, H. Harada, Y. Uesawa, A. Maeda, R. Suzuki<\/u><\/strong>, Y. Okada, K. Takahashi, K. Matsuno, Establishment of a direct-injection electron ionization\u2013mass spectrometry metabolomics method and its application to lichen profiling, Anal. Chem., 89<\/strong>, 6408-6414 (2017).<\/li>
                  5. M. Suzuki, D. Shindo, R. Suzuki<\/u><\/strong>, Y. Shirataki, and H. Waki, Combined long-term caffeine intake and exercise inhibits the development of diabetic nephropathy in OLETF rats, J. Appl. Physiol., 122<\/strong>, 1321-1328 (2017).<\/li><\/ol>\n\n\n\n
                    \n\n\n\n

                    2016\u5e74<\/h3>\n\n\n\n
                    1. R. Suzuki<\/u><\/strong>, Y. Matsushima, N. Okudaira, H. Sakagami and Y. Shirataki, Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata, Anticancer Res., 36: 5931-5936 (2016).<\/li>
                    2. S. Matsuno, R. Suzuki<\/u><\/strong> and Y. Shirataki, Constituents of root of Odontioda Marie Noel \u2018Velano\u2019, Shoyakugaku Zasshi, 70: 79-80 (2016).<\/li>
                    3. R. Suzuki<\/u><\/strong>, H. Kai, Y. Uesawa, K. Matsuno, Y. Okada, Y. Shiratakia, Electron ionization mass spectrometry based metabolomics studies of Sophora flavescens can identify the geographical origin of root samples. Nat. Prod. Commun., 11: 73-75 (2016).<\/li><\/ol>\n\n\n\n
                      \n\n\n\n

                      2015\u5e74<\/h3>\n\n\n\n
                      1. M. Tomomura, R. Suzuki<\/u><\/strong>, Y. Shirataki, H. Sakagami, N. Tamura, A. Tomomura . Rhinacanthin C Inhibits Osteoclast Differentiation and Bone Resorption: Roles of TRAF6\/TAK1\/MAPKs\/NF-\u03baB\/NFATc1 Signaling. PLoS One, 10: e0130174 (2015).<\/li>
                      2. R. Suzuki<\/u><\/strong>, H. Sakagami, Y. Shirataki, New Anti-Oxidative Compounds from Rhinacanthus nasutus. Heterocycles, 91: 1036-1041 (2015).<\/li>
                      3. M. Watanabe, R. Suzuki<\/u><\/strong>, M. Tomomura, H. Sakagami, A. Tomomura, Y. Shirataki, Constituents of the Leaves of Odontioda Marie Noel \u2018Velano\u2019 with Inhibitory Activity on RANKL-induced Osteoclast Differentiation. Shoyakugaku Zasshi, 69: 20-21 (2015).<\/li><\/ol>\n\n\n\n
                        \n\n\n\n

                        2014\u5e74<\/h3>\n\n\n\n
                        1. E. Fukuda, Y. Uesawa, M. Baba, R. Suzuki<\/u><\/strong>, Y. Shirataki, T. Fukuda, Y. Okada, Identification of the country of growth of Sophora flavescens using Direct Analysis in Real Time Mass Spectrometry (DART-MS), Nat. Prod. Commun., 9: 1591-1594 (2014).<\/li>
                        2. R. Suzuki<\/u><\/strong>, S. Matsuno, H. Sakagami, Y. Okada, Y. Shirataki, Search of New Cytotoxic Crude Materials against Human Oral Squamous Cell Carcinoma using 1H NMR-based Metabolomics. Anticancer Res., 34: 4117-4120 (2014).<\/li>
                        3. R. Suzuki<\/u><\/strong>, S. Tomoeda, M. Todoroki, M. Horiguchi, Y. Shirataki, Studies on the Constituents of the Leaves of Odontioda Marie Noel \u2018Velano\u2019. Shoyakugaku Zasshi, 68: 23-24 (2014).<\/li><\/ol>\n\n\n\n

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                          \u8ad6\u6587Articles 2025\u5e74 H. Shirai, M. …<\/p>\n","protected":false},"author":1,"featured_media":91,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-fullwidth.php","meta":[],"_links":{"self":[{"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/pages\/33"}],"collection":[{"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33"}],"version-history":[{"count":78,"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/pages\/33\/revisions"}],"predecessor-version":[{"id":1412,"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/pages\/33\/revisions\/1412"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=\/wp\/v2\/media\/91"}],"wp:attachment":[{"href":"https:\/\/josai-pharm.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}